A morning accident closed Highway 133 around 11am Tuesday morning.
The vehicle involved was a cattle truck which rolled six miles south of Carbondale.
Colorado State Patrol says the driver, 49 year-old Roger A. Rose, was treated and released on scene. He failed to negotiate a right curve in the road and went across the road and off the other side.
The trailer ended up on its side, and blocked both lanes of traffic.
The roof of the trailer opened during the crash. A small number of the cattle were killed, but most of the animals escaped harm and had to be rounded up by ranchers and community members in the area.
The road was reopened around 2:30pm Tuesday.
While the accident remains under investigation, driver inexperience and lane violations are suspected. Excessive speed and/or drug and alcohol use are not considered factors in the crash.