Mychael Danna, who composed the score for best movie nominee "Life of Pi," won for best original score in a movie.
The Austrian film "Amour" won best foreign film, presented by Sly Stallone and Arnold Schwarzenegger.
Pixar film "Brave" carried home the Globe for best animated feature film.
Unlike the Oscars, the Globes also honor television with 11 awards.
HBO's "Game Change" won three TV Globes, including for best made-for-TV miniseries or movie. Julianne Moore was given the best actress in a made-for-TV miniseries or movie award for portraying former vice presidential nominee Sarah Palin. Ed Harris was awarded the best supporting actor Globe for his work on "Game Change."
Kevin Costner won the Globe for best actor in a made-for-TV miniseries or movie for the History Channel's "Hatfields & McCoys."
Showtime's "Homeland" claimed three Globes, including the best TV drama series trophy for a second consecutive year. Co-stars Claire Danes and Damian Lewis won the best actress and best actor in a television drama series honors, respectively.
It is the first Globe for Lewis, who won an Emmy last fall for the same role. He dedicated the award to his late mother, who "I know is up there tonight, looking down, bursting with pride and telling everyone how well her son is doing in acting."
The best supporting actress in a TV series, miniseries or movie award went to Maggie Smith for "Downton Abbey: Season 2."
Lena Dunham, star of "Girls," won for best actress in a TV comedy series.
Don Cheadle claimed the Globe for best actor in a TV comedy or musical series for "House of Lies."
The Globes launch the award season, which includes the Screen Actors Guild awards in two weeks, followed by the Grammys two weeks later and culminates on February 24 with the Academy Awards.
This year's Golden Globes show was hosted by NBC sitcom stars Tina Fey and Amy Poehler. Their onstage humor was less brutal toward the celebrities than in the past three years when British comedian Ricky Gervais turned the show into a roast.
Poehler joked that Gervais proved that "when you run afoul of the Hollywood Foreign Press, they make you host the show two more times."
Poehler's best one-liner, based on the loud audience laughter, targeted Kathryn Bigelow, director of best movie nominee "Zero Dark Thirty," which is controversial because of its portrayal of the torture of terror detainees. "When it comes to torture, I trust the lady who spent three years married to James Cameron," Poehler said
The Hollywood Foreign Press Association, which includes a group of about 85 writers affiliated with publications outside of the United States, selected the nominees and winners of the Globes.