"Think about 2012 when Benghazi was a fresh issue. How much did it help the GOP in the end? Somewhere between nada and zilch. Only a small portion of the electorate seemed interested, and overwhelmingly, they were already voting Republican," Sabato said. "I have a hard time believing that Benghazi will make much difference after the passage of four more years."

Rothkopf agrees.

"I do not believe the Benghazi case will have any impact on her presidential prospects. No one in public life for as long as she has been has an absolutely blemish-free record, and hers is vastly more distinguished and blemish-free than most," Rothkopf said.

"Further, truth be told, the misfires prior to Benghazi really occurred much farther down the food chain within the State Department," he said. "Suggesting errors in judgment regarding a particular post in a particular country fall within the direct purview of the Secretary of State is a gross misreading of the nature and demands of her job."